A compound formed by the substitution of the hydroxyl group of a carboxylic acid (or amine) in the carboxylic acid, or the derivative of ammonia (or amine) with the substituted of the acyl group. Hydrogen bonds can form hydrogen bonds in the amino acid of amide, and the association between molecules can make the boiling point of amide be higher than the corresponding carboxylic acid. Amide is widely distributed in nature, protein is the amide bond ─ CONH ─ (or called a peptide bond) connected to the natural high molecular compound. The amide is heated for a long time in strong acid, which can be hydrolyzed to carboxylic acid and ammonia (or amines). The amide can be obtained from the partial loss of water or from the ammonia solution of acyl halide, acid anhydride and ester. Nitrile can be partially hydrolyzed and stopped in the amide phase.
Amide is mainly used as an industrial solvent, and the pharmaceutical industry is used to produce vitamins and hormones, as well as in the manufacture of insecticidal. In organic reaction, dimethylformamide is not only used as a solvent for reaction, but also an important intermediate for organic synthesis. Pesticide industry can be used to produce insecticidal.